Litterature to date on electrochemotherapy in Veterinary Medicine

CAT
Bibliography and cases studies

Tumor typessquamous cell carcinomafibrosarcomafibrosarcomaganglioneuroblastomalocalized lymphomaMammary adenocarcinomaSquamous cell carcinoma
LinksMORE + MORE + MORE + MORE + MORE + MORE + MORE +
Electrical protocol (devices)8 pulses – 1300V/cm
– 100microsec – 5000 Hz
(Cliniporator IGEA)
8 biphasic pulses –
50+50microsec – 1300 or
800V/cm (Chemopulse)
8 biphasic pulses –
50+50msec – 1300V/cm
(Chemipulse III)
8 biphasic pulses –
50+50microsec
(Spugnini et al.)
8 biphasic pulses –
50+50microsec – 1300V/cm
(Chemopulse)
Square wave pulses –
100microsec – 1300 V/cm
(Jouan GHT 1287)
8 biphasic pulses –
50+50microsec – 1300V/cm
(Chemopulse)
Cases1172641(8 years old)61 (7 years old)1 (4 years old)
Observation time2 months to 3 yearsOver 2 years5 yearsOver 2 years2 years6 months2 years
Results87.5%
objective response
time to recurrence:
12 (intraopeative group) –
19 months
(postoperative group)
(4 months for surgery alone)
time to recurrence:
1,8 years
(180 days for surgery alone)
complete
remission 402 days,
recurrence treated with
cisplatin (450 days)
complete responsecomplete responsecomplete response
Bleomycin BLM / Cisplatin CDDPBLMBLMCDDPBLMBLMCDDPBLM
Intratumoral /
Intravenous
IVITITITITITIT
Session number1223221
TitleElectrochemotherapy with
intravenous bleomycin injection:
an observational study in
superficial squamous cell
carcinoma in cats
Intraoperative versus postoperative
electrochemotherapy in high
grade soft tissue sarcomas:
a preliminary study
in a spontaneous
feline model
Electrochemotherapy
with cisplatin enhances local
control after surgical ablation
of fibrosarcoma in cats:
an approach to improve the therapeutic
index of highly toxic
chemotherapy drugs
Ganglioneuroblastoma
in a cat: A rare
neoplasm treated with
electrochemotherapy
Electrochemotheapy
for localized lymphoma:
a preliminary study in
companion animals
Electrochemotheapy:
Potentiation of local antitumour
effectiveness of cisplatin
in dogs and cats
Potentiation of
Chemotherapy in Companion
Animals with Spontaneous
Large Neoplasms by Application
of Biphasic Electric Pulses
AuthorNatasa Tozon et alEnrico P. Spugnini et alEnrico P. Spugnini et alEnrico P. Spugnini et alEnrico P. Spugnini et al Tozon et al.Enrico P. Spugnini et al
DeviceCliniporatorOnkodisruptorOnkodisruptorOnkodisruptorOnkodisruptorCliniporatorOnkodisruptor

DOG
Bibliography and cases studies

Tumor typesanal sac carcinomaapocrine gland carcinomafibromatosisfibrosarcomalocalized lymphoma
LinksMORE + MORE + MORE + MORE + MORE +
Electrical protocol (devices)8 biphasic pulses –
50+50microsec – 1300V/cm
(Spugnini et al.))
8 biphasic pulses –
50+50microsec
(Spugnini et al.)
8 biphasic pulses –
50+50microsec – 1300V/cm
(Chemipulse III)
8 biphasic pulses –
50+50microsec – 1300V/cm
(Chemopulse)
8 biphasic pulses –
50+50microsec – 1300V/cm
(Chemopulse)
Cases1 (14 years old)1 (10 years old)1 (1 year old)226
Observation time18 monthsOver 1 years18 months7 years2 years
Resultscomplete remission, on
incompletely excised tumor
complete remission (surgery
+ cisplatin + mitoxantrone)
complete remission95% response (on incompletely
excised tumor)
complete response
Bleomycin BLM / Cisplatin CDDPCDDPCDDP + mitoxantroneBLM + CDDPBLMBLM
Intratumoral /
Intravenous
ITITITITIT
Session number24322
TitleAdjuvant Electrochemotherapy
for Incompletely Excised
Anal Sac Carcinoma
in a Dog
Successful Rescue of an
Apocrine Gland Carcinoma
Metastatic to the Cervical
Lymph Nodes by
Mitoxantrone Coupled
with Trains of Permeabilizing
Electrical Pulses
(Electrochemotherapy)
Electrochemotherapy for the
treatment of recurring aponeurotic
fibromatosis in a dog
Adjuvant Electrochemotherapy
for the Treatment of
Incompletely Excised
Spontaneous Canine
Sarcomas
Electrochemotheapy for
localized lymphoma:
a preliminary study in
companion animals
AuthorEnrico P. Spugnini et alEnrico P. Spugnini et alEnrico P. Spugnini et alEnrico P. Spugnini et alEnrico P. Spugnini et al
Tumor typesmast cell tumormast cell tumormelanomaperianal tumorperianal tumor
LinksMORE + MORE + MORE + MORE + MORE +
Electrical protocol (devices)8 pulses – 100microsec
– 1300V/cm (Juan)
ou 1000V/cm (IGEA)
8 biphasic pulses –
50+50microsec – 1300V/cm
(Chemopulse)
8 biphasic pulses –
50+50msec
(Spugnini et al.)
8 pulses – 100microsec –
1300V/cm (Juan)
8 pulses – 100microsec –
1300V/cm (Juan)
ou 1000V/cm (IGEA)
Cases25281 (6 year old)1221
Observation timeover 3 yearsover 22 months2 monthsOver 2 yearsOver 1 years
Results62.5% complete response
(comparison wtih surgery)
85% response rate,
on surgical scar
volume reduction of 50%92% objective response94% objective response
Bleomycin BLM / Cisplatin CDDPCDDPBLMCDDPBLM or CDDPBLM or CDDP
Intratumoral /
Intravenous
ITITITITIT
Session number241 to 41 to 3
TitleElectrochemotherapy Compared
to Surgery for Treatment
of Canine Mast Cell
Tumours
Adjuvant Electrochemotherapy
for the Treatment of
Incompletely Resected
Canine Mast Cell
Tumors
Local Control and
Distant Metastasis
after Electrochemotherapy
of a Canine Anal
Melanoma
Effective Treatment of
Perianal Tumors in Dogs
with Electrochemotherapy
Electrochemotherapy
is highly effective for
the treatment of canine
perianal hepatoid adenoma
and epithelioma
AuthorVeronika Kodre et alEnrico P. Spugnini et alEnrico P. Spugnini et alNatasa Tozon et alNatasa Tozon et al

HORSE
Bibliography and cases studies

Tumor typesmelanomasarcoid
LinksMORE + MORE +
Electrical protocol (devices)-8 pulses –
100microsec – 1300V/cm
(ELECTROvet S13)
Cases1 (22 years old)48
Observation time1 year4 years
Resultspartial remission97.9% complete response
Bleomycin BLM / Cisplatin CDDP-CDDP
Intratumoral /
Intravenous
-IT
Session number-1 to 7
TitleElectrochemotherapy for
the treatment of multiple
melanomes in a Horse
Successful treatment of equine sarcoids
with cispltin electrochemotherapy:
A retrospective study of 48 cases
AuthorEnrico P. Spugnini et alYoussef Tamzali et al

Would you like to try
electrochemotherapy in your clinic ?