Electrochemotherapy (ECT) is employed in veterinary medicine around the world. In 2015, more than 4,000 animals were treated with ECT.
In veterinary medicine, the same protocol used in human medicine is employed (concentrations of cisplatin or bleomycin, application of electric pulses, etc.). However, general anesthesia is mandatory for animals.
Animals may develop local side effects, such as edema, necrosis, and require follow-up visits every two weeks during the recovery period.
However, necrosis does not provoke scratching like an infected wound, and animals treated with ECT show no decrease in their overall condition. Healthy scar tissue gradually replaces the tumor lesion. This healing by secondary intention can last up to several weeks.
ECT can be used alone, in one or more sessions.
It can also be used as adjuvant treatment. In addition to surgery or radiation therapy, ECT’s efficacy is maintained because the rate of cell proliferation is high in these cases. There is therefore no risk of slowing down recovery.
Electrochemotherapy in veterinary medicine was described in more than 30 articles, for treatment of melanoma, fibrosarcoma, mast cell tumor, perianal tumor. Some examples:
> For feline squamous cell carcinoma, more than 87.5% response rate is obtained (Tozon, 2014).
> In the case of mast cell tumors, complete treatment is obtained for 62.5% of dogs within one or two sessions (Tozon, 2009).
Electrochemotherapy in veterinary medicine employs the same protocol used in human medicine (concentrations of cisplatin or bleomycin, application of electric pulses, etc.). However, general anesthesia is mandatory for animals.
Animals may develop similar local side effects, such as edema, necrosis, and need follow-up visits every two weeks during recovery.
Photo : Dr. Fabien RELAVE DMV, DACVS, DECVS – Clinique Equine de Conques, Saint Aubin de Branne, FRANCE